There’s tons of excitement in psychiatry after the US Food and Drug Administration advisory committee recently backed esketamine (Spravato), an intranasal form of ketamine for treatment-resistant depression. This is an exciting and hopeful advancement because there hasn’t been a different pharmacologic depression treatment target approved by the agency in decades (Think: Prozac’s arrival in 1986). Like any new drug, the excitement and hope surrounding esketamine (Spravato) needs to be weighed by risks and benefits. Here are a few things you need to know about esketamine (Spravato).